Thionyl Chloride → 4-Methoxythiophene-2-carbonyl chloride

HRID 2372809Notes

Reaction equation

HRID 2372809 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:8]([OH:10])=O)[S:6][CH:7]=1.S(Cl)([Cl:13])=O>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:8]([Cl:13])=[O:10])[S:6][CH:7]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 126466194-Methoxythiophene-2-carboxylic acid

Product 1

HCID 147218374-Methoxythiophene-2-carbonyl chloride

Procedure

24.0 g (152 mmol) 4-methoxy-2-thiophenecarboxylic acid were suspended in 250 ml thionyl chloride and heated for two hours under reflux. The excess thionyl chloride was then distilled off under vacuum. The crude product was quickly distilled off and crystallised out in the receiver.

Workup

  1. temperatureheated for two hours
  2. temperatureunder reflux
  3. distillationThe excess thionyl chloride was then distilled off under vacuum
  4. distillationThe crude product was quickly distilled off
  5. customcrystallised out in the receiver

Sources & evidence

ORD record
ord-0fb81332dea545dab94f6c6b4b2eedaf
Source dataset
uspto-grants-1992_03
Patent number
US05100911

Reaction notes

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