HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Propanol → 5-(4-(benzyloxy)phenyl)-3-(2-cyanoethyl)-1,3,4-oxadiazol-2(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Propanol | HCID 1031 | — |
| Reactant | Acrylonitrile | HCID 7855 | — |
| Reactant | 4-(Benzyloxy)benzohydrazide | HCID 1526486 | — |
| Product | 5-(4-(benzyloxy)phenyl)-3-(2-cyanoethyl)-1,3,4-oxadiazol-2(3H)-one | HCID 3035812 | 88% |
Reaction Steps
To a solution of 100 mmoles of (4-benzyloxy benzoyl) hydrazine in 200 ml of 1-propanol, 100 mmoles of acrylonitrile are added and the mixture is heated for 24 hours at reflux. Then 50 mmoles of acrylonitrile are added and the heating is continued at reflux for 24 hours. After cooling, the product is filtered and crystallized in a water-ethanol mixture and 26 g (yield: 88%) of the expected product were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05100910 |
| Source dataset | uspto-grants-1992_03 |
| ORD ID | ord-8f0ceb9136ad43e1a08d0502b1d140ba |
| Source note | uspto-grants-1992_03 |