反应详情

温度

100 °C

1.25 g of sodium thiomethylate are added under a nitrogen atmosphere to a solution of 15 g (0.0593 mol) of 1-chloro-4-(phenylsulfonyl)benzene in 150 ml of hexamethylphosphoramide. The mixture obtained is heated for 4 hours at 100° C. and then cooled and hydrolyzed in an ice/water mixture. The reaction medium obtained is extracted with ethyl acetate and the aqueous phase obtained is then poured into a 4 N solution of hydrochloric acid at 0° C. The product formed precipitates. After filtration, washing with water until the pH of the washings is neutral, and drying, 13.44 g (yield: 90.5%) of the expected product are obtained. M.p.=117° C.

1. customThe mixture obtained
2. temperaturecooled
3. customThe reaction medium obtained
4. extractionis extracted with ethyl acetate
5. customthe aqueous phase obtained
6. customThe product formed
7. customprecipitates
8. filtrationAfter filtration
9. washwashing with water until the pH of the washings
10. customdrying