Potassium Carbonate → HCID 19902364, compound

HRID 2372819Notes

Reaction equation

HRID 2372819 reaction equation
O[C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:14])=[C:7]([CH3:13])[C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1.[Br:15][C:16]1[CH:23]=[CH:22][C:19](CCl)=[CH:18][CH:17]=1.[C:24]([O-])([O-])=[O:25].[K+].[K+]>CC(C)=O>[Br:15][C:16]1[CH:23]=[CH:22][C:19]([C:2]2[CH:11]=[C:10]3[C:5]([C:6]([CH3:14])=[C:7]([CH3:13])[C:8](=[O:12])[O:9]3)=[C:4]([O:25][CH3:24])[CH:3]=2)=[CH:18][CH:17]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 68528p-Bromobenzyl chlorideHCID 54129907-hydroxy-3,4-dimethyl-2H-chromen-2-one

Product 1

HCID 19902364HCID 19902364, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 5.0 g of 7-hydroxy-3,4-dimethylcoumarin, 5.4 g of 4-bromobenzyl chloride, 5.4 g of K2CO3 and 100 ml of acetone was stirred for 4 days at room temperature and evaporated down, and the residue was partitioned in H2O/methylene chloride. After the organic phase had been separated off, extraction was carried out twice with methylene chloride, the combined organic phases were evaporated down and the residue was recrystallized from methanol.

Workup

  1. customevaporated down
  2. customthe residue was partitioned in H2O/methylene chloride
  3. customAfter the organic phase had been separated off
  4. extractionextraction
  5. customthe combined organic phases were evaporated down
  6. customthe residue was recrystallized from methanol

Sources & evidence

ORD record
ord-e510b3c1c8634c688fd88368e4974dfc
Source dataset
uspto-grants-1992_03
Patent number
US05100914

Reaction notes

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