2-[4-(Aminomethyl)phenyl]benzonitrile → 4'-(Aminomethyl)-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester

HRID 2372837Notes

Reaction equation

HRID 2372837 reaction equation
[NH2:1]CC1C=CC(C2C=CC=CC=2C#N)=CC=1.Br[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32])=[CH:21][CH:20]=1>>[NH2:1][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 13933412-[4-(Aminomethyl)phenyl]benzonitrileHCID 9906257tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate

Product 1

HCID 99710734'-(Aminomethyl)-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester

Procedure

The title compound is prepared similarly to 4-aminomethyl-2'-cyanobiphenyl except 4-bromomethyl-2't-butoxycarbonylbiphenyl is used in place of 4-aminomethyl-2'-cyanobiphenyl.

Sources & evidence

ORD record
ord-40324e8db63f48b5b92cc8abd0b6bf88
Source dataset
uspto-grants-1992_03
Patent number
US05100897

Reaction notes

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