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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2372837Generated: October 30, 2026

2-[4-(Aminomethyl)phenyl]benzonitrile → 4'-(Aminomethyl)-biphenyl-2-carboxylic acid 1,1-dimethylethyl ester

https://huagongshe.com/reaction/2372837

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-[4-(Aminomethyl)phenyl]benzonitrileHCID 1393341—
Reactanttert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylateHCID 9906257—
Product4'-(Aminomethyl)-biphenyl-2-carboxylic acid 1,1-dimethylethyl esterHCID 9971073—

Reaction Steps

The title compound is prepared similarly to 4-aminomethyl-2'-cyanobiphenyl except 4-bromomethyl-2't-butoxycarbonylbiphenyl is used in place of 4-aminomethyl-2'-cyanobiphenyl.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05100897
Source datasetuspto-grants-1992_03
ORD IDord-40324e8db63f48b5b92cc8abd0b6bf88
Source noteuspto-grants-1992_03