HCID 9980359, compound → HCID 19370817, compound

HRID 2372849Notes

Reaction equation

HRID 2372849 reaction equation
[CH2:1]([C:5]1[N:10]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:24]([OH:26])=[O:25])=[CH:14][CH:13]=2)[C:9](=[O:27])[C:8]([C:28]([O:30]CC)=[O:29])=[CH:7][N:6]=1)[CH2:2][CH2:3][CH3:4]>FC(F)(F)C(O)=O>[CH2:1]([C:5]1[N:10]([CH2:11][C:12]2[CH:13]=[CH:14][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:24]([OH:26])=[O:25])=[CH:16][CH:17]=2)[C:9](=[O:27])[C:8]([C:28]([OH:30])=[O:29])=[CH:7][N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 1

HCID 9980359HCID 9980359, compound

Product 1

HCID 19370817HCID 19370817, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

The title compound is prepared from 2-butyl-3-(2'-carboxybiphen-4-yl)methyl-5-ethoxycarbonylpyrimidin-4(3H)-one similarly to that in Example 9 by ester hydrolysis. The t-butyl ester is hydrolyzed in neat trifluoroacetic acid to give the title compound.

Sources & evidence

ORD record
ord-040cca0cb31a494db1370773befa1a3a
Source dataset
uspto-grants-1992_03
Patent number
US05100897

Reaction notes

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