Trifluoroacetic acid → HCID 131717220, compound

HRID 2372850Notes

Reaction equation

C([O:5][C:6]([C:8]1[CH:27]=[CH:26][CH:25]=[CH:24][C:9]=1[C:10]1[CH:15]=[CH:14][C:13]([CH2:16][NH:17][C:18](=[NH:23])[CH2:19][CH2:20][CH2:21][CH3:22])=[CH:12][CH:11]=1)=[O:7])(C)(C)C.F[C:29](F)(F)[C:30]([OH:32])=O>>[CH2:19]([C:18]1[N:17]([CH2:16][C:13]2[CH:12]=[CH:11][C:10]([C:9]3[CH:24]=[CH:25][CH:26]=[CH:27][C:8]=3[C:6]([OH:5])=[O:7])=[CH:15][CH:14]=2)[C:6](=[O:5])[CH:8]=[C:9]([O:32][CH2:30][CH3:29])[N:23]=1)[CH2:20][CH2:21][CH3:22]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 178446843HCID 178446843, compound

Product 1

HCID 131717220HCID 131717220, compound

Procedure

The title compound is prepared from N-(2'-t-butoxycarbonylbiphen-4-yl)methylvaleramidine and ethyl 3,3-diethocyacrylate (Aldrich) similarly to that in Example 16. The t-butyl ester is hydrolyzed in neat trifluoroacetic acid to give the title compound.

Sources & evidence

ORD record: ord-ee3697e433bf41c483182e386d4bbf0a
Source dataset: uspto-grants-1992_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05100897

Reaction notes

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