Hydrochloric Acid → Indapamide

HRID 2372912Notes

Reaction equation

HRID 2372912 reaction equation
[NH2:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH:3]1[CH3:11].Cl.S([O-])(=O)(=O)C.[Cl:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][C:20]=1[S:28](=[O:31])(=[O:30])[NH2:29]>>[NH2:29][S:28]([C:20]1[CH:21]=[C:22]([CH:26]=[CH:27][C:19]=1[Cl:18])[C:23]([NH:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH:3]1[CH3:11])=[O:24])(=[O:31])=[O:30]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 85257MethanesulfonateHCID 1693151-Amino-2-methylindolineHCID 30179793-(Aminosulfonyl)-4-chlorobenzoyl chloride

Product 1

HCID 3702Indapamide

Procedure

The process as claimed in claim 1, wherein -amino-2,3-dihydro-2-methyl-1H-indole is reacted in the form of a hydrochloride or mesylate with 4-chloro-3-sulfamoylbenzoyl chloride.

Sources & evidence

ORD record
ord-c60ce15cada74f4aba316a240c876b52
Source dataset
uspto-grants-1992_03
Patent number
US05101040

Reaction notes

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