Toluene → HCID 14678244, compound

HRID 2373037Notes

Reaction equation

HRID 2373037 reaction equation
[CH3:1][CH:2]([CH2:5][S:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=1)[CH:3]=[O:4].FC(F)(F)C1C=CC(SC(C)[CH2:27][CH:28]=[O:29])=CC=1.[C:33]1(C)C=CC=CC=1>>[OH:4][CH:3]([CH:2]([CH3:1])[CH2:5][S:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:14])[F:15])=[CH:9][CH:8]=1)[CH2:33][C:28](=[O:29])[CH3:27]

Participants

4

Reactant 3

HCID 1140TolueneHCID 14347983HCID 14347983, compoundHCID 14347984HCID 14347984, compound

Product 1

HCID 14678244HCID 14678244, compoundYield 71.1%

Procedure

The same procedure as in Production example 27 was repeated except that 59.6 g of a toluene solution containing 41.6% of 2-methyl-3-(4-trifluoromethylphenylthio)propanal was used in place of the toluene solution containing 3-(4-trifluoromethylphenylthio)butanal. Thus, 36.67 g of crude 4-hydroxy-5-methyl-6-(4-trifluromethylphenylthio)-2-hexanone were obtained (purity: 59.3%, yield: 71.1%).

Sources & evidence

ORD record
ord-efeef441c1f54f639e0e8a837d338496
Source dataset
uspto-grants-1992_03
Patent number
US05101076

Reaction notes

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