反应详情

1.00 Gram of 4-hydroxy-6-(2-methylphenylthio)-2-hexanone was dissolved in 100 ml of toluene, and 0.02 g of p-toluene sulfonic acid was added thereto. The resulting mixture was refluxed for 2.5 hours with stirring. After having been cooled, the mixture was washed with a saturated aqueous sodium hydrogencarbonate solution and then saturated aqueous sodium chloride solution. Then the mixture was dried over anhydrous magnesium sulfate. Removing the solvent from the mixture under reduced pressure gave 0.97 g of 6-(2-methylphenylthio)-3-hexen-2-one. (trans : cis =3.8 : 1) (purity: 94.7%). The yield was 99.8%.

1. temperatureThe resulting mixture was refluxed for 2.5 hours
2. temperatureAfter having been cooled
3. washthe mixture was washed with a saturated aqueous sodium hydrogencarbonate solution
4. dry with materialThen the mixture was dried over anhydrous magnesium sulfate
5. customRemoving the solvent from the mixture under reduced pressure