Hydrochloric Acid → HCID 19005066, compound

HRID 2373069Notes

Reaction equation

HRID 2373069 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:10]([CH2:12][F:13])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl>CCOCC>[NH2:1][CH:2]([CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[C:10](=[O:11])[CH2:12][F:13]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131717226HCID 131717226, compound

Product 1

HCID 19005066HCID 19005066, compoundYield 64.1%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a solution of Boc-PheCH2F (0.75 g, 2.67 mmol) in anhydrous ether (5 mL) was added a saturated solution of HCl in ether (30 mL). The mixture was stirred vigorously at room temperature for 45 minutes. The suspension was filtered, washed with ether (10 mL), and pumped dry, to give a white solid (0.31 g, 54%). This material was immediately used in the next step.

Workup

  1. filtrationThe suspension was filtered
  2. washwashed with ether (10 mL)
  3. custompumped dry

Sources & evidence

ORD record
ord-6be698046bbc407889466c30f6294d59
Source dataset
uspto-grants-1992_03
Patent number
US05101068

Reaction notes

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