Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzoic Acid | HCID 243 | — |
| Reactant | Olanzapine | HCID 135398745 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 178422259 | HCID 178422259 | — |
Reaction Steps
To a clear solution of olanzapine free base (5.0 g) in acetone (150 ml) was added slowly a solution of 1.0 equivalent of benzoic acid (1.96 g) in acetone (20 ml) at room temperature. After stirring at 4° C. overnight, the crystals were isolated by filtration, washed with acetone (20 ml) and dried overnight at 40° C. Yield: 6.23 g (90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07459449B2 |
|---|
| Source dataset | uspto-grants-2008_12 |
|---|
| ORD ID | ord-f9089c0ec7764793ac0959d00aa29b2d |
|---|
| Source note | uspto-grants-2008_12 |
|---|
