Benzoic Acid → HCID 178422259, compound

HRID 2373148Notes

Reaction equation

HRID 2373148 reaction equation
[CH3:1][C:2]1[S:6][C:5]2[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:14]=[C:15]([N:16]3[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]3)[C:4]=2[CH:3]=1.[C:23]([OH:31])(=[O:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>CC(C)=O>[CH3:1][C:2]1[S:6][C:5]2[C:4](=[C:15]([N:16]3[CH2:17][CH2:18][N:19]([CH3:22])[CH2:20][CH2:21]3)[NH:14][C:13]3[C:8]([N:7]=2)=[CH:9][CH:10]=[CH:11][CH:12]=3)[CH:3]=1.[CH:27]1[CH:28]=[CH:29][C:24]([C:23]([OH:31])=[O:30])=[CH:25][CH:26]=1

Participants

4

Reactant 2

HCID 243Benzoic AcidHCID 135398745Olanzapine

Product 1

HCID 178422259HCID 178422259, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Conditions

Temperature
4 °C

Procedure

To a clear solution of olanzapine free base (5.0 g) in acetone (150 ml) was added slowly a solution of 1.0 equivalent of benzoic acid (1.96 g) in acetone (20 ml) at room temperature. After stirring at 4° C. overnight, the crystals were isolated by filtration, washed with acetone (20 ml) and dried overnight at 40° C. Yield: 6.23 g (90%).

Workup

  1. customthe crystals were isolated by filtration
  2. washwashed with acetone (20 ml)
  3. customdried overnight at 40° C

Sources & evidence

ORD record
ord-f9089c0ec7764793ac0959d00aa29b2d
Source dataset
uspto-grants-2008_12
Patent number
US07459449B2

Reaction notes

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