反应详情

温度

150 °C

A mixture of 2-amino-4-nitrobenzoic acid (5.0 g, 27.5 mmol) and formamide (8.0 ml, 201.5 mmol) in a microwave reaction vessel was heated in a microwave reactor at 150° C. for 1 hr. The slurry was cooled to rt, stirred with aq. NaHCO3, filtered, washed with water followed by ether and dried in vacuum oven to provide 3.7 g of 7-nitroquinazolin-4(3H)-one (Compound 98-1).

1. customin a microwave reaction vessel
2. temperatureThe slurry was cooled to rt
3. filtrationfiltered
4. washwashed with water
5. customdried in vacuum oven