Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | L-Lactic Acid | HCID 107689 | — |
| Reactant | Olanzapine | HCID 135398745 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 137194544 | HCID 137194544 | — |
Reaction Steps
To a clear solution of 5.0 g of olanzapine base in 150 ml acetone was added, at room temperature, a solution of 1.44 g of L-(+)-lactic acid in 50 ml of acetone. The reaction mixture was stirred at −20° C. and the solid was isolated. Yield: 3.36 g (52%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07459449B2 |
|---|
| Source dataset | uspto-grants-2008_12 |
|---|
| ORD ID | ord-061c37941fa74cd89611d45c26e6b4de |
|---|
| Source note | uspto-grants-2008_12 |
|---|
