L-Lactic Acid → HCID 137194544, compound

HRID 2373151Notes

Reaction equation

[CH3:1][C:2]1[S:6][C:5]2[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:14]=[C:15]([N:16]3[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]3)[C:4]=2[CH:3]=1.[C:23]([OH:28])(=[O:27])[C@H:24]([CH3:26])[OH:25]>CC(C)=O>[CH3:1][C:2]1[S:6][C:5]2[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:14]=[C:15]([N:16]3[CH2:17][CH2:18][N:19]([CH3:22])[CH2:20][CH2:21]3)[C:4]=2[CH:3]=1.[C:23]([O-:28])(=[O:27])[CH:24]([CH3:26])[OH:25]

Participants

Conditions

Temperature: -20 °C

Procedure

To a clear solution of 5.0 g of olanzapine base in 150 ml acetone was added, at room temperature, a solution of 1.44 g of L-(+)-lactic acid in 50 ml of acetone. The reaction mixture was stirred at −20° C. and the solid was isolated. Yield: 3.36 g (52%).

Workup

customthe solid was isolated

Sources & evidence

ORD record: ord-061c37941fa74cd89611d45c26e6b4de
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07459449B2

Reaction notes

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