Glycolic Acid → HCID 136352455, compound

HRID 2373152Notes

Reaction equation

HRID 2373152 reaction equation
[CH3:1][C:2]1[S:6][C:5]2[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:14]=[C:15]([N:16]3[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]3)[C:4]=2[CH:3]=1.[C:23]([OH:27])(=[O:26])[CH2:24][OH:25]>CC(C)=O>[CH3:1][C:2]1[S:6][C:5]2[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:14]=[C:15]([N:16]3[CH2:17][CH2:18][N:19]([CH3:22])[CH2:20][CH2:21]3)[C:4]=2[CH:3]=1.[C:23]([O-:27])(=[O:26])[CH2:24][OH:25]

Participants

4

Reactant 2

HCID 757Glycolic AcidHCID 135398745Olanzapine

Product 1

HCID 136352455HCID 136352455, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Conditions

Temperature
4 °C

Procedure

To a solution of 5.0 g of olanzapine in 150 ml of acetone was added 1.22 g of glycolic acid in 25 ml acetone slowly at room temperature. The mixture was stirred overnight at 4° C. The crystals were isolated by filtration, washed with 15 ml of acetone and 20 ml of ether and dried overnight at 40° C. in vacuo. Yield: 5.76 g

Workup

  1. customThe crystals were isolated by filtration
  2. washwashed with 15 ml of acetone and 20 ml of ether
  3. customdried overnight at 40° C. in vacuo

Sources & evidence

ORD record
ord-3cf0d304f55b4082ad7110d1f49aefa1
Source dataset
uspto-grants-2008_12
Patent number
US07459449B2

Reaction notes

Loading…