Glycolic Acid → HCID 136352455, compound

HRID 2373153Notes

Reaction equation

HRID 2373153 reaction equation
[CH3:1][C:2]1[S:6][C:5]2[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:14]=[C:15]([N:16]3[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]3)[C:4]=2[CH:3]=1.[C:23]([OH:27])(=[O:26])[CH2:24][OH:25]>CC(C)=O>[CH3:1][C:2]1[S:6][C:5]2[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:14]=[C:15]([N:16]3[CH2:17][CH2:18][N:19]([CH3:22])[CH2:20][CH2:21]3)[C:4]=2[CH:3]=1.[C:23]([O-:27])(=[O:26])[CH2:24][OH:25]

Participants

4

Reactant 2

HCID 757Glycolic AcidHCID 135398745Olanzapine2×

Product 1

HCID 136352455HCID 136352455, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

To a clear solution of 75 g olanzapine free base in 1500 ml acetone, was added slowly 18.0 g glycolic acid in 100 ml acetone at room temperature. The resulting mixture was stirred at room temperature overnight. The formed crystals were isolated by filtration and dried overnight at 40° C. in vacuo. Isolated yield: 84.1 gram (90%). 1H-NMR confirms the molar ratio olanzapine:acid=1:1.

Workup

  1. customThe formed crystals were isolated by filtration
  2. customdried overnight at 40° C. in vacuo
  3. customIsolated yield: 84.1 gram (90%)

Sources & evidence

ORD record
ord-2c52ce0473ba490ba0fc185ddb73e220
Source dataset
uspto-grants-2008_12
Patent number
US07459449B2

Reaction notes

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