Acetic Acid → HCID 136352454, compound

HRID 2373154Notes

Reaction equation

HRID 2373154 reaction equation
[CH3:1][C:2]1[S:6][C:5]2[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:14]=[C:15]([N:16]3[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]3)[C:4]=2[CH:3]=1.[C:23]([OH:26])(=[O:25])[CH3:24]>CC(C)=O>[CH3:1][C:2]1[S:6][C:5]2[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:14]=[C:15]([N:16]3[CH2:17][CH2:18][N:19]([CH3:22])[CH2:20][CH2:21]3)[C:4]=2[CH:3]=1.[C:23]([O-:26])(=[O:25])[CH3:24]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 135398745Olanzapine

Product 1

HCID 136352454HCID 136352454, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
4 °C

Procedure

To a solution of 5.0 g of olanzapine base in 150 ml acetone was added slowly 1.o6 g of acetic acid at room temperature and the mixture was stirred overnight at 4° C. The crystals were isolated by filtration, washed with 20 ml acetone and 20 ml of ether and dried overnight at 40° C. in vacuo. Yield: 3.32 g (56%).

Workup

  1. customThe crystals were isolated by filtration
  2. washwashed with 20 ml acetone and 20 ml of ether
  3. customdried overnight at 40° C. in vacuo

Sources & evidence

ORD record
ord-25720d38da5c4476bb35128e2858c8bf
Source dataset
uspto-grants-2008_12
Patent number
US07459449B2

Reaction notes

Loading…