Ethanesulfonic acid → HCID 137194546, compound

HRID 2373156Notes

Reaction equation

HRID 2373156 reaction equation
[CH3:1][C:2]1[S:6][C:5]2[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:14]=[C:15]([N:16]3[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]3)[C:4]=2[CH:3]=1.[CH2:23]([S:25]([OH:28])(=[O:27])=[O:26])[CH3:24]>CC(C)=O>[CH3:1][C:2]1[S:6][C:5]2[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:14]=[C:15]([N:16]3[CH2:17][CH2:18][N:19]([CH3:22])[CH2:20][CH2:21]3)[C:4]=2[CH:3]=1.[S:25]([CH2:23][CH3:24])([O-:28])(=[O:27])=[O:26]

Participants

4

Reactant 2

HCID 11668Ethanesulfonic acidHCID 135398745Olanzapine

Product 1

HCID 137194546HCID 137194546, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

To a solution of 5.0 g of olanzapine base in 150 ml acetone was added 1.76 g ethane sulfonic acid in 50 ml acetone at room temperature. Immediately a solid started to form. After stirring for 3 hours, the crystals were isolated by filtration and washed with 50 ml acetone. Yield: 6.59 g (97%).

Workup

  1. customto form
  2. customthe crystals were isolated by filtration
  3. washwashed with 50 ml acetone

Sources & evidence

ORD record
ord-42eb0222d0924b0c86fd851cbf3ed77e
Source dataset
uspto-grants-2008_12
Patent number
US07459449B2

Reaction notes

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