HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanesulfonic acid → HCID 137194546, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanesulfonic acid | HCID 11668 | — |
| Reactant | Olanzapine | HCID 135398745 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 137194546 | HCID 137194546 | — |
Reaction Steps
To a solution of 5.0 g of olanzapine base in 150 ml acetone was added 1.76 g ethane sulfonic acid in 50 ml acetone at room temperature. Immediately a solid started to form. After stirring for 3 hours, the crystals were isolated by filtration and washed with 50 ml acetone. Yield: 6.59 g (97%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07459449B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-42eb0222d0924b0c86fd851cbf3ed77e |
| Source note | uspto-grants-2008_12 |