Sulfuric Acid → HCID 136352456, compound

HRID 2373158Notes

Reaction equation

HRID 2373158 reaction equation
[CH3:1][C:2]1[S:6][C:5]2[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:14]=[C:15]([N:16]3[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]3)[C:4]=2[CH:3]=1.[S:23](=[O:27])(=[O:26])([OH:25])[OH:24]>CC(C)=O>[CH3:1][C:2]1[S:6][C:5]2[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=3[N:14]=[C:15]([N:16]3[CH2:17][CH2:18][N:19]([CH3:22])[CH2:20][CH2:21]3)[C:4]=2[CH:3]=1.[S:23]([O-:27])([OH:26])(=[O:25])=[O:24]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 135398745Olanzapine

Product 1

HCID 136352456HCID 136352456, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Conditions

Temperature
4 °C

Procedure

To a solution of 5.0 g olanzapine base in 150 ml acetone was added at room temperature 0.435 ml of 95% sulfuric acid. The mixture was stirred overnight at 4° C. The formed crystals were isolated by filtration, washed with 20 ml of acetone and 20 ml of ether and dried overnight at 40° C. in vacuo. Yield: 5.87 g (approx. 0.25 eq. acetone present).

Workup

  1. customThe formed crystals were isolated by filtration
  2. washwashed with 20 ml of acetone and 20 ml of ether
  3. customdried overnight at 40° C. in vacuo

Sources & evidence

ORD record
ord-b84eaca66748478584fb62e198b38cb2
Source dataset
uspto-grants-2008_12
Patent number
US07459449B2

Reaction notes

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