Sulfuric Acid → HCID 136352456, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5.0 g olanzapine base in 150 ml acetone was added at room temperature 0.435 ml of 95% sulfuric acid. The mixture was stirred overnight at 4° C. The formed crystals were isolated by filtration, washed with 20 ml of acetone and 20 ml of ether and dried overnight at 40° C. in vacuo. Yield: 5.87 g (approx. 0.25 eq. acetone present).

Provenance & Evidence