Methanesulfonic Acid → Linaprazan mesylate

Participants

Reaction Conditions

Reaction Steps

100 g of 2,3-dimethyl-8-(2,6-dimethylbenzylamino)-N-hydroxyethyl-imidazo[1,2-a]pyridine-6-carboxamide was suspended in 200 ml ethanol. The suspension was heated to approximately 60° C. and a mixture of methanesulphonic acid (28.9 g) and ethanol (40 ml) was charged during approximately 80 minutes. After rinsing with ethanol (10 ml), the suspension was cooled to approximately 50° C. The crystals were isolated and washed with ethanol. The crystals were dried (dry-blowing) during 1.5 h. 102 g of 2,3-dimethyl-8-(2,6-dimethylbenzylamino)-N-hydroxyethyl-imidazo[1,2-a]pyridine-6-carboxamide mesylate salt form A was obtained.

Provenance & Evidence