反应详情

温度

60 °C

100 g of 2,3-dimethyl-8-(2,6-dimethylbenzylamino)-N-hydroxyethyl-imidazo[1,2-a]pyridine-6-carboxamide was suspended in 200 ml ethanol. The suspension was heated to approximately 60° C. and a mixture of methanesulphonic acid (28.9 g) and ethanol (40 ml) was charged during approximately 80 minutes. After rinsing with ethanol (10 ml), the suspension was cooled to approximately 50° C. The crystals were isolated and washed with ethanol. The crystals were dried (dry-blowing) during 1.5 h. 102 g of 2,3-dimethyl-8-(2,6-dimethylbenzylamino)-N-hydroxyethyl-imidazo[1,2-a]pyridine-6-carboxamide mesylate salt form A was obtained.

1. additionwas charged during approximately 80 minutes
2. washAfter rinsing with ethanol (10 ml)
3. temperaturethe suspension was cooled to approximately 50° C
4. customThe crystals were isolated
5. washwashed with ethanol
6. customThe crystals were dried
7. custom(dry-blowing) during 1.5 h