Methylphenidate → Methylphenidate Hydrochloride

HRID 2373200Notes

Reaction equation

HRID 2373200 reaction equation
[CH3:1][O:2][C:3]([CH:5]([CH:12]1[NH:17][CH2:16][CH2:15][CH2:14][CH2:13]1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)=[O:4].[ClH:18].C(O)(C)C>C(O)(C)C>[CH3:1][O:2][C:3]([CH:5]([CH:12]1[NH:17][CH2:16][CH2:15][CH2:14][CH2:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4].[ClH:18]

Participants

4

Reactant 2

HCID 4158MethylphenidateHCID 21912024Isopropanol hydrochloride

Product 1

HCID 9280Methylphenidate Hydrochloride

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
12.5 °C

Procedure

In a reaction vessel, 100 gm methylphenidate, 1000 ml isopropyl alcohol were mixed at 30 to 35° C., cool the mixture to 10 to 15° C. To this mixture Isopropanol hydrochloride solution (18-20% HCl (dry) in isopropyl alcohol) was added by maintaining the reaction mass below 15° C. This was maintained for about 5 hours at 30° C., cooled to 10° C. and filtered to isolate methylphenidate hydrochloride. The precipitate was washed with isopropyl alcohol and dried at 60 to 70° C.

Workup

  1. temperatureby maintaining the reaction mass below 15° C
  2. temperatureThis was maintained for about 5 hours at 30° C.
  3. temperaturecooled to 10° C.
  4. filtrationfiltered

Sources & evidence

ORD record
ord-f8c7e0959a4b4694a56094302fc56156
Source dataset
uspto-grants-2008_12
Patent number
US07459467B2

Reaction notes

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