反应详情

Using a known method, (R)-3-[2-(2-hydroxymethylpyrrolidin-1-yl)ethyl]-5-methylisocoumarin was converted to a hydrochloride to give (R)-3-[2-(2-hydroxymethylpyrrolidin-1-yl)ethyl]-5-methylisocoumarin hydrochloride. 1H-NMR (DMSO-d6)δ: 1.70-2.18 (4H, m), 2.47 (3H, s), 3.08-3.22 (3H, m), 3.60-3.85 (5H, m), 5.51 (1H, brs), 6.82 (1H, s), 7.47 (1H, t, J=8 Hz), 7:69 (1H, d, J=7 Hz), 7.99 (1H, d, J=8 Hz), 10.31 (1H, brs).