2-Bromoethanol → 3-[1-(2-hydroxyethyl)piperidin-4-yl]-2H-isoquinolin-1-one

HRID 2373256Notes

Reaction equation

HRID 2373256 reaction equation
Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([C:8]2[NH:9][C:10](=[O:18])[C:11]3[C:16]([CH:17]=2)=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH2:4][CH2:3]1.Br[CH2:20][CH2:21][OH:22]>>[OH:22][CH2:21][CH2:20][N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[NH:9][C:10](=[O:18])[C:11]3[C:16]([CH:17]=2)=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 108982-BromoethanolHCID 230821133-(Piperidin-4-yl)isoquinolin-1(2H)-one hydrochloride

Product 1

HCID 103334413-[1-(2-hydroxyethyl)piperidin-4-yl]-2H-isoquinolin-1-oneYield 34.5%

Procedure

By the reaction in the same manner as in Example 2a, using 3-(piperidin-4-yl)-2H-isoquinolin-1-one hydrochloride (1.1 g) and 2-bromoethanol (1.0 g) as starting materials, 3-[1-(2-hydroxyethyl)piperidin-4-yl]-2H-isoquinolin-1-one (0.39 g) was obtained.

Workup

  1. customBy the reaction in the same manner as in Example 2a

Sources & evidence

ORD record
ord-59528abc2dc74312918d7cb19724f859
Source dataset
uspto-grants-2008_12
Patent number
US07459465B2

Reaction notes

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