2-Bromoethanol → HCID 10445940, compound

HRID 2373271Notes

Reaction equation

HRID 2373271 reaction equation
Cl.[CH3:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]=[C:6]([CH:14]1[CH2:18][CH2:17][NH:16][CH2:15]1)[NH:7][C:8]2=[O:13].Br[CH2:20][CH2:21][OH:22]>>[OH:22][CH2:21][CH2:20][N:16]1[CH2:17][CH2:18][CH:14]([C:6]2[NH:7][C:8](=[O:13])[C:9]3[C:4]([CH:5]=2)=[C:3]([CH3:2])[CH:12]=[CH:11][CH:10]=3)[CH2:15]1

Participants

3

Reactant 2

HCID 108982-BromoethanolHCID 22931207HCID 22931207, compound

Product 1

HCID 10445940HCID 10445940, compound

Procedure

By the reaction in the same manner as in Example 2a, using 5-methyl-3-(pyrrolidin-3-yl)-2H-isoquinolin-1-one hydrochloride (200 mg) and 2-bromoethanol (270 μl), 3-[1-(2-hydroxyethyl)pyrrolidin-3-yl]-5-methyl-2H-isoquinolin-1-one (39 mg) was obtained.

Workup

  1. customBy the reaction in the same manner as in Example 2a

Sources & evidence

ORD record
ord-b57bbec6989c4363b93038b5722c3017
Source dataset
uspto-grants-2008_12
Patent number
US07459465B2

Reaction notes

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