2-Bromoethanol → HCID 11777281, compound

HRID 2373272Notes

Reaction equation

HRID 2373272 reaction equation
Cl.[NH:2]1[CH2:6][CH2:5][CH:4]([C:7]2[NH:8][C:9](=[O:17])[C:10]3[C:15]([CH:16]=2)=[CH:14][CH:13]=[CH:12][CH:11]=3)[CH2:3]1.Br[CH2:19][CH2:20][OH:21]>>[OH:21][CH2:20][CH2:19][N:2]1[CH2:6][CH2:5][CH:4]([C:7]2[NH:8][C:9](=[O:17])[C:10]3[C:15]([CH:16]=2)=[CH:14][CH:13]=[CH:12][CH:11]=3)[CH2:3]1

Participants

3

Reactant 2

HCID 108982-BromoethanolHCID 22931198HCID 22931198, compound

Product 1

HCID 11777281HCID 11777281, compound

Procedure

By the reaction in the same manner as in Example 2a, using 3-(pyrrolidin-3-yl)-2H-isoquinolin-1 one hydrochloride (201 mg) and 2-bromoethanol (285 μl), 3-[1-(2-hydroxyethyl)pyrrolidin-3-yl]-2H-isoquinolin-1-one (58 mg) was obtained.

Workup

  1. customBy the reaction in the same manner as in Example 2a

Sources & evidence

ORD record
ord-0b9c7216020740ce847a7dad2ddb4e7a
Source dataset
uspto-grants-2008_12
Patent number
US07459465B2

Reaction notes

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