反应详情

212 mg (0.6 mmol) of N-(isoquinolin-3-yl)-2-(4-pyridylmethyl)aminobenzoic acid amide is mixed in 10 ml of dichloromethane with 103 mg (0.6 mmol) of m-chloroperbenzoic acid, and it is stirred for 6 hours at room temperature in a moisture-free environment and under argon. The batch is then washed with 15 ml of saturated sodium bicarbonate solution and with saturated common salt solution, dried, filtered and concentrated by evaporation. The residue is chromatographed on silica gel with methylene chloride:ethanol=10:1 as an eluant. 68 mg (30% of theory) of N-(isoquinolin-3-yl)-2-(4-pyridylmethyl)aminobenzoic acid amide-N-oxide with a melting point of 212.2° C. is obtained.

1. washThe batch is then washed with 15 ml of saturated sodium bicarbonate solution and with saturated common salt solution
2. customdried
3. filtrationfiltered
4. concentrationconcentrated by evaporation
5. customThe residue is chromatographed on silica gel with methylene chloride