Pyridoxal hydrochloride → 3'-Fluoro-4'-[(3-hydroxy-5-hydroxymethyl-2-methyl-pyridin-4-ylmethyl)-amino]-biphenyl-2-sulfonic acid tert-butylamide

HRID 2373305Notes

Reaction equation

HRID 2373305 reaction equation
[CH3:1][C:2]1[C:7]([OH:8])=[C:6]([CH:9]=O)[C:5]([CH2:11][OH:12])=[CH:4][N:3]=1.Cl.[C:14]([NH:18][S:19]([C:22]1[C:23]([C:28]2[CH:33]=[CH:32][C:31]([NH2:34])=[C:30]([F:35])[CH:29]=2)=[CH:24][CH:25]=[CH:26][CH:27]=1)(=[O:21])=[O:20])([CH3:17])([CH3:16])[CH3:15]>>[C:14]([NH:18][S:19]([C:22]1[C:23]([C:28]2[CH:33]=[CH:32][C:31]([NH:34][CH2:9][C:6]3[C:5]([CH2:11][OH:12])=[CH:4][N:3]=[C:2]([CH3:1])[C:7]=3[OH:8])=[C:30]([F:35])[CH:29]=2)=[CH:24][CH:25]=[CH:26][CH:27]=1)(=[O:21])=[O:20])([CH3:17])([CH3:15])[CH3:16]

Participants

3

Reactant 2

HCID 6171Pyridoxal hydrochlorideHCID 108532844'-Amino-3'-fluoro-biphenyl-2-sulfonic acid tert-butylamide

Product 1

HCID 598525353'-Fluoro-4'-[(3-hydroxy-5-hydroxymethyl-2-methyl-pyridin-4-ylmethyl)-amino]-biphenyl-2-sulfonic acid tert-butylamide

Procedure

The reductive amination of pyridoxal hydrochloride (436.4 mg, 2.143 mmol) and 4′-amino-3′-fluoro-biphenyl-2-sulfonic acid tert-butylamide (760 mg, 2.357 mmol), following the procedure described in Example 7, gave 3′-fluoro-4′-[(3-hydroxy-5-hydroxymethyl-2-methyl-pyridin-4-ylmethyl)-amino]-biphenyl-2-sulfonic acid tert-butylamide (9).

Sources & evidence

ORD record
ord-5caffb3cb17c45b7bcb66ce549a47ae2
Source dataset
uspto-grants-2008_12
Patent number
US07459468B2

Reaction notes

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