HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridoxal hydrochloride → 3'-Fluoro-4'-[(3-hydroxy-5-hydroxymethyl-2-methyl-pyridin-4-ylmethyl)-amino]-biphenyl-2-sulfonic acid tert-butylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridoxal hydrochloride | HCID 6171 | — |
| Reactant | 4'-Amino-3'-fluoro-biphenyl-2-sulfonic acid tert-butylamide | HCID 10853284 | — |
| Product | 3'-Fluoro-4'-[(3-hydroxy-5-hydroxymethyl-2-methyl-pyridin-4-ylmethyl)-amino]-biphenyl-2-sulfonic acid tert-butylamide | HCID 59852535 | — |
Reaction Steps
The reductive amination of pyridoxal hydrochloride (436.4 mg, 2.143 mmol) and 4′-amino-3′-fluoro-biphenyl-2-sulfonic acid tert-butylamide (760 mg, 2.357 mmol), following the procedure described in Example 7, gave 3′-fluoro-4′-[(3-hydroxy-5-hydroxymethyl-2-methyl-pyridin-4-ylmethyl)-amino]-biphenyl-2-sulfonic acid tert-butylamide (9).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07459468B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-5caffb3cb17c45b7bcb66ce549a47ae2 |
| Source note | uspto-grants-2008_12 |