HCID 178504267, compound → HCID 11450662, compound

HRID 2373345Notes

Reaction equation

HRID 2373345 reaction equation
C[Si](C)(C)CCOC[NH:7][C:8]([C:10]1[N:14]=[C:13]([C:15]2[CH:16]=[C:17]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[CH:18]=[CH:19][CH:20]=2)[NH:12][N:11]=1)=[O:9]>C(#N)C.O>[C:27]1([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=2[C:17]2[CH:18]=[CH:19][CH:20]=[C:15]([C:13]3[N:14]=[C:10]([C:8]([NH2:7])=[O:9])[NH:11][N:12]=3)[CH:16]=2)[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

4

Reactant 1

HCID 178504267HCID 178504267, compound

Product 1

HCID 11450662HCID 11450662, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6342AcetonitrileSolvent

Procedure

A mixture of 0.035 g of 2-Trimethylsilylethoxymethyl-5-[2′-(Phenyl)biphenyl-3-yl]-1,2,4-triazole-3-carboxamide in 3 mL of acetonitrile and 9 mL of a 50% solution of HF in water was stirred at rt for 6 hours. The reaction mixture was then concentrated and the residue was purified by chromatography (silica, CH3OH: CH2Cl2 0-5% gradient) to give the title compound.

Workup

  1. concentrationThe reaction mixture was then concentrated
  2. customthe residue was purified by chromatography (silica, CH3OH: CH2Cl2 0-5% gradient)

Sources & evidence

ORD record
ord-f7ae981f71e14b1f9fb3103692dc32fa
Source dataset
uspto-grants-2008_12
Patent number
US07459475B2

Reaction notes

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