Hydrochloric Acid → HCID 59851769, compound

HRID 2373426Notes

Reaction equation

C(OC(=O)[NH:7][CH2:8][C:9]#[C:10][C:11]1[CH:12]=[CH:13][C:14]2[C:20]3[N:21]=[C:22]([NH:25][C:26]4[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[C:28]([O:34][CH3:35])[CH:27]=4)[N:23]=[CH:24][C:19]=3[CH2:18][C:17](=[O:36])[NH:16][C:15]=2[CH:37]=1)(C)(C)C.Cl>>[NH2:7][CH2:8][C:9]#[C:10][C:11]1[CH:12]=[CH:13][C:14]2[C:20]3[N:21]=[C:22]([NH:25][C:26]4[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[C:28]([O:34][CH3:35])[CH:27]=4)[N:23]=[CH:24][C:19]=3[CH2:18][C:17](=[O:36])[NH:16][C:15]=2[CH:37]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 59852025HCID 59852025, compound

Product 1

HCID 59851769HCID 59851769, compound

Procedure

In a manner similar to that described for Method K, {3-[2-(3,4-dimethoxy-phenylamino)-6-oxo-6,7-dihydro-5H-benzo[b]pyrimido[4,5-d]azepin-9-yl]-prop-2-ynyl}-carbamic acid tert-butyl ester (I-39) was converted to the HCl salt of I-38 (30%): HRMS Calcd. for C23H21N5O3: 416.1720, Found 416.1722.

Sources & evidence

ORD record: ord-1d73db95b41f4043a3ed77b320487178
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07459448B2

Reaction notes

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