Hydrochloric Acid → HCID 59851374, compound

HRID 2373428Notes

Reaction equation

HRID 2373428 reaction equation
COC1C=C(NC2N=CC3CC(=O)NC4C=C(I)C=CC=4C=3N=2)C=CC=1OC.CNCC#C.[CH3:34][O:35][C:36]1[CH:37]=[C:38]([NH:44][C:45]2[N:46]=[CH:47][C:48]3[CH2:54][C:53](=[O:55])[NH:52][C:51]4[CH:56]=[C:57]([C:60]#[C:61][CH2:62][NH:63][CH3:64])[CH:58]=[CH:59][C:50]=4[C:49]=3[N:65]=2)[CH:39]=[CH:40][C:41]=1[O:42][CH3:43].Cl>>[CH3:34][O:35][C:36]1[CH:37]=[C:38]([NH:44][C:45]2[N:46]=[CH:47][C:48]3[CH2:54][C:53](=[O:55])[NH:52][C:51]4[CH:56]=[C:57]([CH2:60][CH2:61][CH2:62][NH:63][CH3:64])[CH:58]=[CH:59][C:50]=4[C:49]=3[N:65]=2)[CH:39]=[CH:40][C:41]=1[O:42][CH3:43]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 96160N-methylpropyn-2-ylamineHCID 56946380HCID 56946380, compoundHCID 66935437HCID 66935437, compound

Product 1

HCID 59851374HCID 59851374, compound

Procedure

In a manner similar to that described for Method O, 2-(3,4-dimethoxy-phenylamino)-9-iodo-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one (I-30) and N-methylprop-2-yn-1-amine were converted to 2-(3,4-dimethoxy-phenylamino)-9-(3-methylamino-prop-1-ynyl)-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one. The crude product (unstable) was carried on in a similar manner to that described for Method P to give I-87, which was converted to the HCl salt (40%): MS Rt═0.98 min, m/z═434 (M+H).

Workup

  1. customto give I-87, which

Sources & evidence

ORD record
ord-b4591cd0293a4e55bb3c69a955a3e6fa
Source dataset
uspto-grants-2008_12
Patent number
US07459448B2

Reaction notes

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