4-Iodoanisole → 7-(4-Methoxy-phenylethynyl)-3,3-dimethyl-3,4-dihydro-2H-benzo[b][1,4]dioxepine

HRID 2373444Notes

Reaction equation

HRID 2373444 reaction equation
[C:1]([C:3]1[CH:15]=[CH:14][C:6]2[O:7][CH2:8][C:9]([CH3:13])([CH3:12])[CH2:10][O:11][C:5]=2[CH:4]=1)#[CH:2].I[C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=1>>[CH3:24][O:23][C:20]1[CH:21]=[CH:22][C:17]([C:2]#[C:1][C:3]2[CH:15]=[CH:14][C:6]3[O:7][CH2:8][C:9]([CH3:12])([CH3:13])[CH2:10][O:11][C:5]=3[CH:4]=2)=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 696764-IodoanisoleHCID 598526957-Ethynyl-3,3-dimethyl-3,4-dihydro-2H-benzo[b][1,4]dioxepine

Product 1

HCID 113926787-(4-Methoxy-phenylethynyl)-3,3-dimethyl-3,4-dihydro-2H-benzo[b][1,4]dioxepine

Procedure

The title compound is prepared in analogy to example 1 from 7-ethynyl-3,3-dimethyl-3,4-dihydro-2H-benzo[b][1,4]dioxepine (6) (example 1d) and 1-iodo-4-methoxy-benzene. MS (ESI) 308.2 (M•)+.

Sources & evidence

ORD record
ord-94593c9aa7b7429eba72c4216269c73f
Source dataset
uspto-grants-2008_12
Patent number
US07459480B2

Reaction notes

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