4-Iodophenol → 4-(3,3-Dimethyl-3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-ylethynyl)-phenol

HRID 2373446Notes

Reaction equation

HRID 2373446 reaction equation
[C:1]([C:3]1[CH:15]=[CH:14][C:6]2[O:7][CH2:8][C:9]([CH3:13])([CH3:12])[CH2:10][O:11][C:5]=2[CH:4]=1)#[CH:2].I[C:17]1[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=1>>[CH3:13][C:9]1([CH3:12])[CH2:8][O:7][C:6]2[CH:14]=[CH:15][C:3]([C:1]#[C:2][C:17]3[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=3)=[CH:4][C:5]=2[O:11][CH2:10]1

Participants

3

Reactant 2

HCID 108944-IodophenolHCID 598526957-Ethynyl-3,3-dimethyl-3,4-dihydro-2H-benzo[b][1,4]dioxepine

Product 1

HCID 692924094-(3,3-Dimethyl-3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-ylethynyl)-phenol

Procedure

The title compound is prepared in analogy to example 1 from 7-ethynyl-3,3-dimethyl-3,4-dihydro-2H-benzo[b][1,4]dioxepine (6) (example 1d) and 4-iodo-phenol as a brown solid. MS (ESI) 293.1 (M−H)−.

Sources & evidence

ORD record
ord-0d4e95259f434055a1a75154b5d8a68d
Source dataset
uspto-grants-2008_12
Patent number
US07459480B2

Reaction notes

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