Ammonium Chloride → HCID 178506543, compound

HRID 2373454Notes

Reaction equation

HRID 2373454 reaction equation
[I:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[N-:10]=[N+:11]=[N-:12].[Na+].[Cl-].[NH4+]>CN(C=O)C>[I:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]2[NH:12][N:11]=[N:10][N:7]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 764674-Iodobenzonitrile

Product 1

HCID 178506543HCID 178506543, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 4-iodobenzonitrile (2.0 g), sodium azide (624 mg) and ammonium chloride (514 mg) in DMF is stirred 22 h at 100° C. DMF is evaporated and the residue is suspended in H2O and treated with conc. aq. HCl. The solid material is collected by filtration, washed with 1 N aq. HCl sol. and H2O and dried under high vacuum.

Workup

  1. customDMF is evaporated
  2. additiontreated with conc. aq. HCl
  3. filtrationThe solid material is collected by filtration
  4. washwashed with 1 N aq. HCl sol. and H2O
  5. customdried under high vacuum

Sources & evidence

ORD record
ord-e8ae126a5e034cc19a17ec7f389a8ff9
Source dataset
uspto-grants-2008_12
Patent number
US07459480B2

Reaction notes

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