(4-Ethynylphenyl)(morpholino)methanone → 4-ethynyl-N,N-dimethylbenzamide

HRID 2373462Notes

Reaction equation

HRID 2373462 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]([N:11]2[CH2:16]COC[CH2:12]2)=[O:10])=[CH:5][CH:4]=1)#[CH:2].CN(C)C(=O)C1C=CC(C#C[Si](C)(C)C)=CC=1>>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]([N:11]([CH3:16])[CH3:12])=[O:10])=[CH:5][CH:4]=1)#[CH:2]

Participants

3

Reactant 2

HCID 57764578(4-Ethynylphenyl)(morpholino)methanoneHCID 69292322N,N-Dimethyl-4-trimethylsilanylethynyl-benzamide

Product 1

HCID 202539284-ethynyl-N,N-dimethylbenzamide

Procedure

The title compound is prepared in analogy to (4-ethynyl-phenyl)-morpholin-4-yl-methanone (Example 16c) from N,N-Dimethyl-4-trimethylsilanylethynyl-benzamide. 1H-NMR (300 MHz): 3.15 (s, 1H); 3.33-3.94 (br, 8H); 7.37 (d, J=6.6, 2H); 7.53 (d, J=6.6, 2H).

Sources & evidence

ORD record
ord-8acb0c8525174fe0b6f79586e98d9c99
Source dataset
uspto-grants-2008_12
Patent number
US07459480B2

Reaction notes

Loading…