2-Bromoethyl methyl ether → 7-[4-(2-Methoxy-ethoxy)-phenylethynyl]-3,3-dimethyl-3,4-dihydro-2H-benzo[b][1,4]dioxepine

HRID 2373464Notes

Reaction equation

HRID 2373464 reaction equation
[CH3:1][C:2]1([CH3:22])[CH2:8][O:7][C:6]2[CH:9]=[CH:10][C:11]([C:13]#[C:14][C:15]3[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=3)=[CH:12][C:5]=2[O:4][CH2:3]1.[CH3:23][O:24][CH2:25][CH2:26]Br>>[CH3:23][O:24][CH2:25][CH2:26][O:21][C:18]1[CH:17]=[CH:16][C:15]([C:14]#[C:13][C:11]2[CH:10]=[CH:9][C:6]3[O:7][CH2:8][C:2]([CH3:22])([CH3:1])[CH2:3][O:4][C:5]=3[CH:12]=2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 692924094-(3,3-Dimethyl-3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-ylethynyl)-phenol

Product 1

HCID 692929737-[4-(2-Methoxy-ethoxy)-phenylethynyl]-3,3-dimethyl-3,4-dihydro-2H-benzo[b][1,4]dioxepine

Procedure

The title compound was prepared according to the general procedure described in example 18 by alkylation of 4-(3,3-dimethyl-3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-ylethynyl)-phenol (Example 6) with 2-methoxyethyl bromide as brownish solid, MS (ESI) 353.3 (M+H)+.

Sources & evidence

ORD record
ord-9478f8b060e54e6983b825227aa65085
Source dataset
uspto-grants-2008_12
Patent number
US07459480B2

Reaction notes

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