Trifluoroacetic acid → HCID 178504815, compound

HRID 2373516Notes

Reaction equation

HRID 2373516 reaction equation
C(OC(=O)[NH:7][C:8]1([C:14]2[N:19]=[C:18]([C:20]([NH:22][CH2:23][C:24]3[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:25]=3[S:31]([CH3:34])(=[O:33])=[O:32])=[O:21])[C:17]([OH:35])=[C:16]([OH:36])[N:15]=2)[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1)(C)(C)C.[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41]>ClCCl>[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41].[NH2:7][C:8]1([C:14]2[N:19]=[C:18]([C:20]([NH:22][CH2:23][C:24]3[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:25]=3[S:31]([CH3:34])(=[O:33])=[O:32])=[O:21])[C:17]([OH:35])=[C:16]([OH:36])[N:15]=2)[CH2:9][CH2:10][O:11][CH2:12][CH2:13]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178452621HCID 178452621, compound

Product 1

HCID 178504815HCID 178504815, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of tert-butyl-4-[4-({[4-fluoro-2-(methylsulfonyl)benzyl]amino}carbonyl)-5,6-dihydroxypyrimidin-2-yl]tetrahydro-2H-pyran-4-yl-carbamate (C-31) in dichloromethane was treated with an excess of trifluoroacetic acid for 3 hours at room temperature. The acid in excess was removed in vacuo to obtain the crude title compound (C-32) as a pale yellow solid, after trituration with ethyl ether.

Workup

  1. customThe acid in excess was removed in vacuo

Sources & evidence

ORD record
ord-d55e6e071d7f4c5c8afa23c00418ac71
Source dataset
uspto-grants-2008_12
Patent number
US07459452B2

Reaction notes

Loading…