HCID 10616500, compound → HCID 10612438, compound

HRID 2373518Notes

Reaction equation

HRID 2373518 reaction equation
[C:1]12([C:18]([O:20]C(C)(C)C)=[O:19])[N:7]([C:8]([O:10][CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[O:9])[CH:4]([CH2:5][CH2:6]1)[CH2:3][CH2:2]2>C(O)(C(F)(F)F)=O.C(Cl)Cl.O>[CH2:11]([O:10][C:8]([N:7]1[CH:4]2[CH2:3][CH2:2][C:1]1([C:18]([OH:20])=[O:19])[CH2:6][CH2:5]2)=[O:9])[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 1

HCID 10616500HCID 10616500, compound

Product 1

HCID 10612438HCID 10612438, compound

Reagents, catalysts & solvents 1

HCID 18672661HCID 18672661, compoundSolvent

Procedure

7-benzyl 1-tert-butyl 7-azabicyclo[2.2.1]heptane-1,7-dicarboxylate (C-34)(synthesized following the procedure reported in J. O. C, 1996, 61, 6313-6325) was stirred in TFA/DCM/H2O (95/5/5, 0.3 M) for 10 minutes. Evaporation of the solvent afforded the titled compound (C-35).

Workup

  1. customEvaporation of the solvent

Sources & evidence

ORD record
ord-c5c8d69178ad4d248625415f7525a18c
Source dataset
uspto-grants-2008_12
Patent number
US07459452B2

Reaction notes

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