反应详情

温度

50 °C

The residue obtained in Example 2A was transferred to a 2 L 4-necked round bottom flask and 500 ml of 2N aqueous HCl was added at a temperature ranging from about 25° C. to about 30° C. The reaction mass was heated to a temperature ranging from about 80° C. to about 85° C. and maintained for between 4 to 5 hours. After completion of the reaction (detected by HPLC/TLC), the reaction mass was cooled to a temperature ranging from about 50° C., and 500 ml of toluene was charged to the reaction mass and maintained for 30 minutes at a temperature of about 50° C. The reaction mass was further stirred at a temperature ranging from about 25° C. to about 30° C. for about 30 minutes. The solids were filtered, separated, and then washed twice with 100 ml of toluene. The product was dried to get crude oxcarbazepine of 97-98% purity as determined by HPLC.

1. customranging from about 25° C. to about 30° C
2. temperatureThe reaction mass was heated to a temperature
3. customranging from about 80° C. to about 85° C.
4. temperaturemaintained for between 4 to 5 hours
5. customAfter completion of the reaction (detected by HPLC/TLC)
6. temperaturethe reaction mass was cooled to a temperature
7. customranging from about 50° C.
8. filtrationThe solids were filtered
9. customseparated
10. washwashed twice with 100 ml of toluene
11. customThe product was dried