2-Imidazolidinone → 1-(4-Fluoro-3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone

HRID 2373643Notes

Reaction equation

HRID 2373643 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([F:27])=[C:6]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:25]=[CH:24][CH:23]=[C:22]4[C:17]=3[CH:18]=[CH:19][C:20]([CH3:26])=[N:21]4)[CH2:12][CH2:11]2)[CH:7]=1.[NH:28]1[CH2:32][CH2:31][NH:30][C:29]1=[O:33]>>[F:27][C:5]1[CH:4]=[CH:3][C:2]([N:28]2[CH2:32][CH2:31][NH:30][C:29]2=[O:33])=[CH:7][C:6]=1[CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][N:13]([C:16]2[CH:25]=[CH:24][CH:23]=[C:22]3[C:17]=2[CH:18]=[CH:19][C:20]([CH3:26])=[N:21]3)[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 84532-ImidazolidinoneHCID 574443505-{4-[2-(5-Bromo-2-fluorophenyl)ethyl]-1-piperazinyl}-2-methylquinoline

Product 1

HCID 112819221-(4-Fluoro-3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinoneYield 35%

Procedure

The title compound was prepared in 35% yield according to the general procedure for the preparation of amides, ureas and carbamates (Method A) starting from 5-{4-[2-(5-bromo-2-fluorophenyl)ethyl]-1-piperazinyl}-2-methylquinoline and 2-imidazolidone.

Sources & evidence

ORD record
ord-6b0bc904cb424a6d83559feec907fff9
Source dataset
uspto-grants-2008_12
Patent number
US07459456B2

Reaction notes

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