反应详情

温度

60 °C

3-tert-Butoxycarbonylamino-2,6-dimethyl-4-trifluoromethylpyridine(21.12 g, 72.8 mmol) was dissolved in methanol (70 mL). 10% hydrochloric acid in methanol (140 mL) was added to the solution, followed by stirring for 12 hours at 60° C. The reaction mixture was concentrated under reduced pressure, and the residue was suspended in a solvent mixture of ethyl acetate-ether, followed by collection through filtration and washing with ether, to thereby yield 3-amino-2,6-dimethyl-4-trifluoromethylpyridine dihydrochloride as a colorless powder (15.64 g, 82%).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. additionthe residue was suspended in a solvent mixture of ethyl acetate-ether
3. filtrationfollowed by collection through filtration
4. washwashing with ether