Hydrochloric Acid → HCID 69206360, compound

HRID 2373799Notes

Reaction equation

C(OC(=O)[NH:7][C@@H:8]([C:24]1[O:28][N:27]=[C:26]([CH3:29])[N:25]=1)[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[C:18]([Cl:23])[CH:17]=2)=[CH:12][CH:11]=1)(C)(C)C.Cl>>[Cl:23][C:18]1[CH:17]=[C:16]([C:13]2[CH:14]=[CH:15][C:10]([CH2:9][CH:8]([NH2:7])[C:24]3[O:28][N:27]=[C:26]([CH3:29])[N:25]=3)=[CH:11][CH:12]=2)[CH:21]=[CH:20][C:19]=1[F:22]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 69205195HCID 69205195, compound

Product 1

HCID 69206360HCID 69206360, compoundYield 99.5%

Procedure

2-(3′-Chloro-4′-fluoro-biphenyl-4-yl)-1-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethylamine (33 mg) was prepared from [2-(3′-Chloro-4′-fluoro-biphenyl-4-yl)-1-(R)-(3-methyl-[1,2,4]oxadiazol-5-yl)-ethyl]-carbamic acid tert-butyl ester (43 mg, 0.1 mmol) and hydrochloric acid (0.5 mL, 4.0 M. solution in dioxane) following the typical Boc deprotection procedure N.

Sources & evidence

ORD record: ord-0658e9a009604f8f8e0217a97cfe8c90
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07459472B2

Reaction notes

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