HCID 3730311, compound → HCID 72818345, compound

HRID 2373861Notes

Reaction equation

HRID 2373861 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:4]=[CH:5][C:6]([O:9][C:10]2[CH:18]=[CH:17][C:13]([C:14]([OH:16])=O)=[CH:12][CH:11]=2)=[N:7][CH:8]=1.[CH3:21][O:22][C:23](=[O:43])[CH:24]([NH2:42])[CH2:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]2[CH:37]=[CH:36][C:35]([C:38]([F:41])([F:40])[F:39])=[CH:34][CH:33]=2)=[CH:28][CH:27]=1>>[CH3:21][O:22][C:23](=[O:43])[CH:24]([NH:42][C:14](=[O:16])[C:13]1[CH:12]=[CH:11][C:10]([O:9][C:6]2[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:20])[F:19])=[CH:8][N:7]=2)=[CH:18][CH:17]=1)[CH2:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]2[CH:37]=[CH:36][C:35]([C:38]([F:39])([F:41])[F:40])=[CH:34][CH:33]=2)=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 3730311HCID 3730311, compoundHCID 53436803HCID 53436803, compound

Product 1

HCID 72818345HCID 72818345, compound

Procedure

The title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-benzoic acid (283 mg, 1.0 mmol) and 2-amino-3-(4′-trifluoromethyl-biphenyl-4-yl)-propionic acid methyl ester (360 mg, 1.0 mmol) following general procedure A. (580 mg) 1H-NMR(400 MHz, CD3COCD3): 3.24 (dd, 1H), 3.39 (dd, 1H), 3.74 (s, 3H), 4.98 (m, 1H), 6.64 (d, 1H), 7.50 (m, 2H), 7.60 (m, 2H), 7.69 (m, 3H), 7.78 (d, 2H), 7.88 (d, 2H), 7.98(m, 2H), 8.15 (m, 2H); LC/MS (m/z): 589 (M+1)+.

Sources & evidence

ORD record
ord-ec57ca60e8fd40c6a9b9b2e249b0f5c6
Source dataset
uspto-grants-2008_12
Patent number
US07459472B2

Reaction notes

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