Pyrrolidine → HCID 178508473, compound

HRID 2373900Notes

Reaction equation

[CH3:1][N:2]([CH2:4][CH:5]1[CH2:8][CH:7]([C:9]2[N:13]3[CH:14]=[CH:15][N:16]=[C:17]([NH2:18])[C:12]3=[C:11]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH2:26][C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)[CH:20]=3)[N:10]=2)[CH2:6]1)[CH3:3].N1CC[CH2:35][CH2:34]1>>[N:2]1([CH2:4][C@@H:5]2[CH2:6][C@H:7]([C:9]3[N:13]4[CH:14]=[CH:15][N:16]=[C:17]([NH2:18])[C:12]4=[C:11]([C:19]4[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH2:26][C:27]5[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=5)[CH:20]=4)[N:10]=3)[CH2:8]2)[CH2:1][CH2:35][CH2:34][CH2:3]1

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 11604324HCID 11604324, compound

Product 1

HCID 178508473HCID 178508473, compound

Procedure

Procedures for 3-(3-Dimethylaminomethyl-cyclobutyl)-1-(3-benzyloxyphenyl)-imidazo[1,5-a]pyrazin-8-ylamine were followed, replacing dimethylamine with pyrrolidine, LC-MS (ES, Pos.): m/z 454 [MH+].

Sources & evidence

ORD record: ord-a175e1ef2d6d48aca40f39de79f51108
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07459554B2

Reaction notes

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